DEFINITION OF NEONATAL SEIZURE
TYPES OF NEONATAL SEIZURE
SUBTLE SEIZURE
- Example
- ocular
CLONIC SEIZURE
TONIC SEIZURE
MYOCLONIC SEIZURE
NOTE:Myoclonic seizure carry the worst prognosis in terms of neurological outcome and recurrence. Focal clonic seizure have the best prognosis
COMMON ETIOLOGY
- ASPHYXIA
- METABOLIC
- MALFORMATION
- MISCELLANEOUS
- INFECTION
- ICH
- TOXINS
NOTE:Seizure due to SAH and late onset hypocalcemia having better prognosis usually and seizure due to hypoglycemia ,malformation ,and meningitis have poor prognosis.
MANAGEMENT OF SEIZURE
look at ABC DE
CORRECTION OF HYPOGLYCEMIA
CORRECTION OF HYPOCALCEMIA
ANTIEPILEPTIC DRUGS
DOSE:
PHENYTOIN
DOSE
BENZODIAZEPINES
LORAZEPAM
MIDAZALOM
LEVETIRACETAM
DOSE
FOR REFRACTORY SEIZURE
LIDOCAINE
PARALDEHYDE
VALPR0ATE
TOPIRAMATE
OTHER THERAPIES
PYRIDOXINE
EXCHANGE TRANSFUSION
MAINTENANCE AED
Monotherapy best strategies
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