CHRONIC GRANULOMATOUS DISEASE
Mnemonics: CHRONIC Granulomatous Disease
C -Catalase positive organism( staphylococcus aureus , Serrantia marcescens) recurrent infection .
H- HSCT is only known cure
R- Resemble like Chrons disease
O- Osteomyelitis, pneumonia , LN and skin Infections are most common illnesses encountered
N-NBT test now rarely used.
NADPH oxidase component defects
I -Itraconazole prophylaxis reduces the frequency of fungal infection.
C – Cytometry(flow) using DHR helps in diagnosis.
Corticosteroids useful for treatment of children with antral and urethral obstruction or severe granulomatous colitis .
Granuloma : Granuloma are hallmarks .They cause pyloric outlet obstruction, bladder outlet or ureter obstruction.
Disease: Defective generation of microbicidal oxygen metabolites.
D is 4th letter 4 genes ( 1 XLR 3AR)